Synthesis and anti-angiogenic activity of cortistatin analogs.
نویسندگان
چکیده
Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.
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ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 72 11 شماره
صفحات -
تاریخ انتشار 2008